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This revolutionary selective androgen receptor modulator (SARM) functions similarly to anabolic steroids (AS), but without the adverse side effects. For one, the use of anabolic steroids – particularly oral – results in serious damage in the liver. Benign and malignant tumors are usually found in this organ after repeated use, especially when the steroids contain a 17-alpha-alkyl group. Many of the cases are benign, and once the administration of anabolic steroids is stopped, the tumors disappear. Nevertheless, itch, jaundice and cystic rupture are still feared.
In addition, the anabolic steroids increase the plasma activity of liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatise (AP), and in turn this increase in activity harms the hepatocellular membrane of the liver, leading to reduced liver mass or cholestasis, which prevents the flow of the bile from the liver to the duodenum.
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Anabolic steroids are synthetic versions of testosterone, and the fact that these affect the male reproductive system should not come as a surprise. Prolonged use of these steroids in high dosage can cause hypogonadotropic hypogonadism, a condition that diminishes the functional activity of the testes; there is then the possibility of atrophy in the male reproductive organ, as well as the decrease in the production of sperm cells. But once the use of anabolic steroids is stopped, the normal functions come back after a few months.
Erectile dysfunction can also be an outcome of the continued patronage of the anabolic steroids. Although sexual desire increases with AS use, erectile dysfunction also increases, taking into consideration that it is not androgen-dependent. Even an increase in testosterone cannot prevent impotence – as long as there are hormonal insufficiencies, this dysfunction emerges.
Another effect in the male system is the formation of breasts, or gynecomastia. These anabolic steroids, when converted, increase the level of estrogens (the female hormones), which then stimulate breast growth. For males, the worse part of this condition is that it is irreversible unlike the other effects.
It is not only males that should be concerned with anabolic steroids; females who use these steroids also suffer from abnormalities in the reproductive system. These steroids affect the hypothalamic-pituitary-gonadal axis, and as a consequence the formation of follicles and ovulation are severed, not to mention the irregularities in the menstrual cycle. Also, hypertrophy or the increase in the volume of the clitoris emerges, and in pregnant women there is the danger of pseudohermaphroditism or retardation of the female fetus, and even fetal death.
Less serious effects constitute acne, hair loss, lowering of the voice, facial hair growth, and decreased breast size.
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As regards the cardiovascular system, cardiovascular diseases have also been connected to anabolic steroids use. The effect on blood pressure and on plasma lipoproteins is still being analyzed, but obvious structural changes in the heart is already supported with proof – those who use anabolic steroids tend to have mild hypertrophy or slight enlargement of the left ventricle. There are also detrimental psychological effects in using anabolic steroids such as aggressiveness (associated with masculinity), euphoria, sleeping problems, paranoia and hallucinations.
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Anabolic steroids have been around for decades, but medical experts have cautioned people against using these without prescription due to adverse side effects. And recently, the existence of MK-2866 helped eradicate hormonal problems without the need to bear the corollary health hazards. MK-2866 can do whatever the anabolic steroids are able to do, but since MK-2866 is selective, it does not pose threats to the other parts of your body. It will just treat your ailment.
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